Home' Trinidad and Tobago Guardian : March 28th 2016 Contents A24 body & soul
guardian.co.tt Tuesday, March 28, 2017
Shared genetic origin
for ALS/MND and
Researchers have shown for the first time that
Amyotrophic Lateral Sclerosis (ALS), also known
as Motor Neurone Disease (MND) and schizophre-
nia have a shared genetic origin,indicating that the
causes of these diverse conditions are biologically
linked.The work hasjust been published in the pres-
tigious journal Nature Communications.
By analysing the genetic profiles of almost 13,000 ALS/
MND cases and over 30,000 schizophrenia cases, the re-
search led by scientists from Trinity College Dublin in
Ireland confirms that many of the genes that are associated
with these two very different conditions are the same.
In fact, the research which involved collaborators from
the University of Utrecht, Kings College London and
members of the Project MinE and Psychiatric Genome
Consortia has shown an overlap of 14 per cent in genetic
susceptibility to the adult onset neuro-degeneration con-
dition ALS/MND and the developmental neuropsychiatric
While overlaps between schizophrenia and other neu-
ropsychiatric conditions including bipolar affective dis-
order and autism have been shown in the past, this is the
first time that an overlap in genetic susceptibility between
ALS/MND and psychiatric conditions has been shown.
Dr Russell McLaughlin, Ussher Assistant Professor
in Genome Analysis at Trinity College Dublin, and lead
author of the paper said: "This study demonstrates the
power of genetics in understanding the causes of diseases.
While neurological and psychiatric conditions may have
very different characteristics and clinical presentations,
our work has shown that the biological pathways that
lead to these diverse conditions have much in common."
Professor of Neurology in Trinity and Consultant
Neurologist at the National Neuroscience Centre, Orla
Hardiman, who is the senior author and lead investigator
on the project said: "Our work over the years has shown
us that ALS/MND is a much more complex disease than
we originally thought. Our recent observations of links
with psychiatric conditions in some families have made us
think differently about how we should study ALS/MND.
When combined with our clinical work and our studies
using MRI and EEG, it becomes clear that ALS/MND is
not just a disorder of individual nerve cells, but a disorder
of the way these nerve cells talk to one another as part of
a larger network."
She continued: "So instead of thinking of ALS/MND
as a degeneration of one cell at a time, and looking for a
'magic bullet' treatment that works, we should think about
ALS/MND in the same way that we think about schizo-
phrenia, which is a problem of disruptions in connectivity
between different regions of the brain, and we should look
for drugs that help to stabilise the failing brain networks"
The new research was prompted by earlier epidemio-
logical studies by researchers at Trinity, led by Professor
Hardiman. These studies showed that people with ALS/
MND were more likely than expected to have other family
members with schizophrenia, and to have had another
family member who had committed suicide.
This was first noted as family histories were ascertained
from people with ALS/MND in the Irish National ALS
Clinic and was subsequently investigated as part of case
control studies in Ireland in which over 192 families with
ALS/MND and 200 controls participated.
This work was subsequently published in the prestig-
ious American journal the Annals of Neurology in 2013.
This led the Trinity group to team up with European
collaborators in ALS/MND to see if these epidemiological
observations could be due to a genetic overlap between
ALS/MND and schizophrenia.
The Trinity group, along with their partners in the
University of Utrecht, will continue to study the links
between ALS/MND and psychiatric conditions using
modern genetics, epidemiology and neuroimaging, and
in this way will develop new and more effective treatments
that are based on stabilising disrupted brain networks.
(Trinity College Dublin via Science Daily)
Amyotrophic Lateral Sclerosis (ALS), also known as Motor Neurone Disease
(MND) and schizophrenia have a shared genetic origin--- the causes of these
diverse conditions are biologically linked.
TRINIDAD AND TOBAGO CIVIL AVIATION AUTHORITY
INVITATION TO TENDER No. 03/2017
Provision of Security Ser vices
The Trinidad and Tobago Civil Aviation Authority (TTCAA) intends to invite sealed tenders
for the Provision of Security Services.
Interested eligible candidates may obtain complete tender documents from the TTCAA
Administrative Building, Caroni North Bank Road, Piarco, during normal working hours
(Monday -- Friday 9:00 am to 3:00 pm) over the period Monday March 20 -- Wednesday
March 29, 2017 upon payment of a non-refundable Tender Collection Fee of TT$900.00
payable by LINX or Credit Card ONLY.
Completed tender documents in plain sealed envelopes, marked Tender No. 03/2017 for
the Provision of Security Services should be addressed to:
TRINIDAD AND TOBAGO CIVIL AVIATION AUTHORITY
CARONI NORTH BANK ROAD
and deposited in Tender Box No. 1 (the Red Tender Box) at the TTCAA's main reception
desk by 2:30 pm on Monday April 24, 2017. Tenders will be opened in the Board
Room of the TTCAA Administrative Building on 3:00 pm on the same day, in the presence
of candidates' representatives who choose to attend.
This procurement process is not intended to create and shall not create a formal legally
binding bidding process and shall instead be governed by the law applicable to direct
commercial negotiations. For greater clarity and without limitation:
1. The RFP/Tender shall not give rise to any "Contract A"-based tendering law duties or
any other legal obligations arising out of any process contract or collateral contract: and
2. Neither the Tenderer nor TTCAA shall have the right to make any breach of Contract,
tort or any other claims against the other with respect to the award of a contract, failure
to award contract or failure to honour a response to the RFP/Tender.
The TTCAA reser ves the right to reject or accept any tender and is not
bound to give reasons for its decision. Late tenders will not be accepted.
The TTCAA also reserves the right to cancel the bidding process in its
entirety or partially without defraying any cost incurred by any tenderer
in submitting or preparing to submit a tender.
Chairman, Tenders Committee
Trinidad and Tobago Civil Aviation Authority
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