Home' Trinidad and Tobago Guardian : August 12th 2017 Contents A22 body & soul
guardian.co.tt Saturday, August 12, 2017
Researchers at The Ohio State University Wex-
ner Medical Center and Ohio State's College of
Engineering have developed a new technology,
Tissue Nanotransfection (TNT), that can gener-
ate any cell type of interest for treatment within
the patient's own body. This technology may be
used to repair injured tissue or restore function
of aging tissue, including organs, blood vessels
and nerve cells.
Results of the regenerative medicine study were pub-
lished in the journal Nature Nanotechnology.
"By using our novel nanochip technology, injured or
compromised organs can be replaced. We have shown
that skin is a fertile land where we can grow the elements
of any organ that is declining," said Dr Chandan Sen,
director of Ohio State's Center for Regenerative Medi-
cine & Cell Based Therapies, who co-led the study with
L James Lee, professor of chemical and biomolecular
engineering with Ohio State's College of Engineering
in collaboration with Ohio State's Nanoscale Science
and Engineering Center.
Researchers studied mice and pigs in these experi-
ments. Researchers were able to reprogramme skin cells
to become vascular cells in badly injured legs that lacked
blood flow. Within one week, active blood vessels ap-
peared in the injured leg, and by the second week, the
leg was saved. In lab tests, this technology was also
shown to reprogramme skin cells in the live body into
nerve cells that were injected into brain-injured mice
to help them recover from stroke.
"This is difficult to imagine, but it is achievable,
successfully working about 98 per cent of the time.
With this technology, we can convert skin cells into
elements of any organ with just one touch. This process
only takes less than a second and is non-invasive, and
then you're off. The chip does not stay with you, and
the reprogramming of the cell starts. Our technology
keeps the cells in the body under immune surveillance,
so immune suppression is not necessary," said Sen.
TNT technology has two major components: First is
a nanotechnology-based chip designed to deliver cargo
to adult cells in the live body. Second is the design of
specific biological cargo for cell conversion. This car-
go, when delivered using the chip, converts an adult
cell from one type to another, said first author Daniel
Gallego-Perez, an assistant professor of biomedical
engineering and general surgery who also was a post-
doctoral researcher in both Sen's and Lee's laboratories.
Researchers plan to start clinical trials next year to test
this technology in humans, Sen said.
(Ohio State University Wexner Medical Center)
In the largest functional brain imaging study
to date, the Amen Clinics (Newport Beach, CA)
compared 46,034 brain SPECT (single photon
emission computed tomography) imaging stud-
ies provided by nine clinics, quantifying differ-
ences between the brains of men and women. The
study is published in the Journal of Alzheimer's
Lead author, psychiatrist Daniel Amen, MD, founder
of Amen Clinics, Inc, commented, "The quantifiable
differences we identified between men and women
are important for understanding gender-based risk
for brain disorders such as Alzheimer's disease. Us-
ing functional neuroimaging tools, such as SPECT,
are essential to developing precision medicine brain
treatments in the future."
The brains of women in the study were significantly
more active in many more areas of the brain than men,
especially in the prefrontal cortex, involved with fo-
cus and impulse control, and the limbic or emotional
areas of the brain, involved with mood and anxiety.
The visual and coordination centres of the brain
were more active in men.
SPECT can measure blood perfusion in the brain.
Images acquired from subjects at rest or while per-
forming various cognitive tasks will show different
blood flow in specific brain regions.
Subjects included 119 healthy volunteers and 26,683
patients with a variety of psychiatric conditions such
as brain trauma, bipolar disorders, mood disorders,
schizophrenia/psychotic disorders, and attention
deficit hyperactivity disorder. A total of 128 brain
regions were analysed for subjects at baseline and
while performing a concentration task. (IOS Press)
Researchers demonstrate a process known as tissue nanotransfection at The
Ohio State University Wexner Medical Center. In laboratory tests, this process
was able to heal the badly injured legs of mice in just three weeks with a single
touch of this chip. The technology works by converting normal skin cells into
vascular cells, which helped heal the wounds.
Breakthrough device heals
organs with a single touch
Women have more
active brains than men
Links Archive August 11th 2017 August 13th 2017 Navigation Previous Page Next Page