Home' Trinidad and Tobago Guardian : August 20th 2014 Contents A36
body & soul
Guardian www.guardian.co.tt Wednesday, August 20, 2014
Older people are likely to benefit from a high-
dose flu vaccine to ward off the seasonal malaise,
which can be particularly dangerous to those over
65, researchers said.
The findings in the New England Journal of Med-
icine are from the first randomised, controlled trial
to compare high and standard doses of flu vaccine
in older people.
"Until this trial came out we didn t know if it was
going to be clinically better or not, and now we know
it is better," said lead author Keipp Talbot, assistant
professor of medicine at Vanderbilt University.
The study was funded by Sanofi Pasteur and com-
pared the company s Fluzone High-Dose inactivated
influenza vaccine to the standard-dose Fluzone vac-
cine. The high-dose contains four times the amount
of antigen as the standard dose.
The high-dose flu vaccine was 24 per cent more
effective than the standard-dose vaccine in protecting
those over 65 against influenza and its complications,
which can include pneumonia and heart failure.
It was also found to be safe and induced "signif-
icantly higher antibody responses" than the standard
dose did. Side effects included greater arm soreness
following the injection.
The study involved nearly 32,000 people at 126
research centres in the United States and Canada.
The flu causes tens of thousands of deaths each
year and more than 200,000 hospitalisations, accord-
ing to background information in the article.
"These new data are important because they show
that the improved antibody response that is evident
in blood samples does in fact translate into a better
clinical outcome---prevention of influenza virus infec-
tion in recipients of the high-dose vaccine," said
Nicole Bouvier, assistant professor of medicine, infec-
tious diseases and microbiology at the Icahn School
of Medicine at Mount Sinai in New York. She was
not involved in the research.
Ambreen Khalil, an infectious disease specialist at
Staten Island University Hospital in New York, also
described the study as "very well done."
"However it is important to bear in mind that
these results are based on results from 2011 to 2013,
while influenza activity is variable every year," she
Running more than four miles a day could be
dangerous to your health, according to a study out
that examined how much exercise is too much.
Researchers focused on 2,400 heart attack sur-
vivors and found that the more exercise they did,
the less risk they faced of dying from heart dis-
ease---up to a point.
Benefits began to decline among those who ran
more than 30 miles per week.
Among walkers, the turning point, when benefits
were lost, was seen in those who did more than 46
miles per week, or 6.5 miles per day.
Even more, there was a statistically significant
cardiovascular risk associated with the highest levels
of exercise, said the study led by Paul Williams of
the Lawrence Berkeley National Laboratory and Paul
Thompson of the Department of Cardiology at Hart-
"Results suggest that the benefits of running or
walking do not accrue indefinitely and that above
some level, perhaps 30 miles per week of running,
there is a significant increase in risk," the study said.
"Competitive running events also appear to
YOUR DAILY HEALTH
News and Advice
Too much running could be bad
than four miles
a day can prove
increase the risk of an acute
The researchers cautioned that
since their study focused on heart
attack survivors, their results
might not be generalisable to the
population at large.
Experts generally recommend
two and a half hours of moderate
exercise each week, or 75 minutes
weekly of vigorous exercise for a
healthy heart and body.
"For patients with heart dis-
ease, almost all should be exer-
cising, and generally most should
be exercising 30to 40 minutes
most days," said Carl Lavie, a car-
diologist at the John Ochsner
Heart and Vascular Institute in
"But from a health stand-
point, there is no reason to exer-
cise much longer than that and
especially not more than 60 min-
utes on most days."
The research was published in
the peer-reviewed journal Mayo
Clinic Proceedings. (AFP)
people should get
high-dose flu shot
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